Endocrine Abstracts

INTRODUCTION:Diabetes Mellitus is one of the most important problems which has greater health care impact in Spain. It is concluded from the DCCT study on DM1 and UKPDS in DM2 that control of HbA1c levels is essential to reduce chronic complications. Guidelines suggest maintaining HbA1c levels below 7%.PATIENTS AND METHODS:Design: Epidemiological, longitudinal, prospective and multicenter study in Spain, with two cohorts, DM1 (n=40...

Islet amyloid deposition is a characteristic feature of Type 2 diabetes. Accumulation of IAPP by abnormal intracellular peptide degradation in beta-cell could promote fibril formation. IAPP is present in high concentrations in beta-cell lysosomes. To determine if fibrils form in lysosomes and the pathway for the accumulation human islets were cultured under conditions of elevated production of insulin (11mM glucose) and inhibition of secretion (0.6mM diazoxide) and/or lysosoma...